B6542
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B6542
Sigma
Brefeldin A
≥99% (HPLC and TLC), for molecular biology
| Synonym: | Ascotoxin, BFA, Cyanein, Decumbin, γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone |
| CAS Number: | 20350-15-6 |
| Linear Formula: | C16H24O4 |
| Molecular Weight: | 280.36 |
| Beilstein Registry Number: | 25191 |
| MDL number: | MFCD00083258 |
| PubChem Substance ID: | 24891917 |
Description
| Analysis Note | Tested for inhibition of interleukin export from Jurkat cells. |
| Biochem/physiol Actions | Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells. |
Properties
| biological source | from Penicillium brefeldianum |
| grade | for molecular biology |
| assay | ≥99% (HPLC and TLC) |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | UN2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | GY8410000 |
References
| reference | Misumi, T., et al., Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes. J. Biol. Chem. 261, 11398-11403, (1986) Abstract |
| Merck | Merck 13,1355 |
| Beilstein | Beil. 18,IV,1220 |
